Texas Instruments recommends a 4-layer PCB with a solid ground plane, and placing the device close to the analog input sources. Additionally, it's essential to keep the analog and digital traces separate, and to use a common mode filter to reduce noise.
The PGA gain settings depend on the input signal range and the desired output signal range. Consult the datasheet for the PGA gain settings table, and consider using the TI's PGA gain calculator tool to determine the optimal gain settings for your application.
A high-quality, low-jitter clock source is recommended, such as a crystal oscillator or a low-jitter clock generator. Ensure the clock source is properly decoupled, and consider using a clock buffer to reduce jitter and noise.
Follow the recommended power-up and power-down sequencing in the datasheet, ensuring that the analog power supply (AVDD) is powered up before the digital power supply (DVDD), and that the digital power supply is powered down before the analog power supply.
The ADS1240E/1KG4 has a maximum junction temperature of 150°C. Ensure proper heat dissipation by using a heat sink, and following the recommended thermal layout and design guidelines in the datasheet.