The recommended operating voltage range for the CD4049UBEE4 is 4.5V to 15.5V.
To ensure proper biasing, connect the VCC pin to a stable voltage source, and decouple it with a 0.1uF capacitor to ground. Also, ensure the input signals are within the recommended voltage range.
The maximum frequency of operation for the CD4049UBEE4 is typically around 10MHz, but it can vary depending on the specific application and operating conditions.
To handle thermal considerations, ensure good airflow around the device, and consider using a heat sink if the device is expected to dissipate significant power. Also, follow the recommended thermal design guidelines from Texas Instruments.
The CD4049UBEE4 has built-in ESD protection, but it's still important to follow proper ESD handling procedures during assembly and testing to prevent damage to the device.