The maximum clock frequency that can be used with the internal oscillator is 60 MHz, but it's recommended to use a crystal oscillator for frequencies above 48 MHz for better accuracy and stability.
The pin multiplexing can be configured using the PINSELx registers, where x is the number of the port (0-2). Each PINSELx register controls the function of a group of pins. Consult the datasheet and the user manual for the specific pin configurations and register settings.
The minimum voltage required for the ADC to operate correctly is 2.4V, but it's recommended to use a voltage of at least 2.7V for optimal performance.
A bootloader can be implemented using the ISP (In-System Programming) mode, which allows the microcontroller to be programmed through the UART interface. The bootloader code can be stored in a separate flash sector, and the application code can be stored in the remaining flash sectors.
The maximum current that can be sourced or sunk by the GPIO pins is 4mA per pin, but the total current sourced or sunk by all pins should not exceed 100mA.