A good PCB layout should ensure minimal noise coupling, and thermal management should include a thermal pad on the bottom of the module. A heat sink or thermal vias can be used to dissipate heat.
Use a quarter-wave monopole or patch antenna with a good ground plane, and ensure the antenna is placed away from other RF-interfering components. A 50-ohm impedance matching network may be required.
Power up the module in the following sequence: VCC, then VBAT, and finally enable the GPS receiver. Ensure a stable power supply and decoupling capacitors to prevent noise and oscillations.
Use the module's configuration registers to set the desired GPS mode. Consult the datasheet and application notes for specific register settings and commands.
Use proper shielding, grounding, and filtering to minimize EMI. Ensure the module is placed away from other RF-emitting components, and follow FCC and CE regulations for EMC compliance.