The maximum operating frequency of the SN74HC14DRE4 is 100 MHz.
Yes, the SN74HC14DRE4 is compatible with 5V systems, but it's recommended to use a voltage regulator to ensure a stable 5V supply.
The SN74HC14DRE4 has a thermal pad on the bottom of the package, which should be connected to a heat sink or a thermal pad on the PCB to ensure proper heat dissipation.
It's recommended to follow the PCB layout guidelines provided in the datasheet, including keeping the input and output traces short and away from noise sources, and using a solid ground plane.
Yes, the SN74HC14DRE4 is suitable for high-reliability applications, but it's recommended to follow the recommended operating conditions and to perform thorough testing and validation.