The maximum frequency of operation for the SN74HC245DBR is 50 MHz.
Yes, the SN74HC245DBR is compatible with 5V systems, but it's recommended to use a voltage regulator to ensure a stable 5V supply.
The enable pins (EN1 and EN2) are active-low, meaning they need to be pulled low to enable the corresponding direction of data transfer. Connect them to GND or a logic low signal to enable the device.
The SN74HC245DBR can sink or source up to 25 mA of current per output pin.
Yes, the SN74HC245DBR is compatible with 3.3V systems, but the output voltage will be limited to 3.3V. Ensure that the receiving device can handle the reduced voltage.