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The maximum frequency of operation for the SN74HC377N is 40 MHz.
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Yes, the SN74HC377N is compatible with 5V systems, but it's recommended to use a voltage regulator to ensure a stable 5V supply.
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The output enable (OE) pin should be connected to GND to enable the outputs. If left floating, the outputs will be in a high-impedance state.
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The SN74HC377N can sink or source up to 25 mA per output pin.
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Yes, the SN74HC377N is compatible with 3.3V systems, but the output voltage will be limited to 3.3V.