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The maximum frequency of operation for the SN74HC4066PW is 30 MHz.
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Yes, the SN74HC4066PW is compatible with 5V systems, but it's recommended to use a voltage regulator to ensure a stable 5V supply.
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To ensure signal integrity, use a low-impedance PCB design, minimize trace lengths, and use termination resistors if necessary.
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The SN74HC4066PW is rated for operation up to 125°C, but it's recommended to derate the device for high-temperature applications.
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The recommended power-on sequence is to apply VCC before applying any input signals.